Nolatrexed dihydrochloride
- Product Name
- Nolatrexed dihydrochloride
- CAS No.
- 152946-68-4
- Chemical Name
- Nolatrexed dihydrochloride
- Synonyms
- AG 337;CS-254;Thymitaq;NOLATREXED HCL;NOLATREXED 2HCL;Nolatrexed (AG-337);Nolatrexed hydrochloride;Nolatrexed 2hydrochloride;AG337;NOLATREXED (AG 337);NOLATREXED DIHYDROCHLORIDE
- CBNumber
- CB1313745
- Molecular Formula
- C14H14Cl2N4OS
- Formula Weight
- 357.26
- MOL File
- 152946-68-4.mol
Nolatrexed dihydrochloride Property
- Melting point:
- 301-3020C
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Methanol, Water
- form
- Solid
- pka
- 4.1; 5.9; 9.8(at 25℃)
- color
- Off-White to Pale Yellow
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 152946-68-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 29247
- Product name
- Nolatrexed (hydrochloride)
- Packaging
- 10mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 29247
- Product name
- Nolatrexed (hydrochloride)
- Packaging
- 100mg
- Price
- $765
- Updated
- 2024/03/01
- Product number
- 29247
- Product name
- Nolatrexed (hydrochloride)
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 29247
- Product name
- Nolatrexed (hydrochloride)
- Packaging
- 50mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 018433
- Product name
- Nolatrexed Dihydrochloride
- Packaging
- 10mg
- Price
- $382
- Updated
- 2021/12/16
Nolatrexed dihydrochloride Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
Antifolate thymidylate synthase inhibitor. Antineoplastic.
Biological Activity
thymidylate synthase (ts) is a crucial enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for dna biosynthesis. thus, this enzyme is a critical target in cancer chemotherapy. nolatrexed (ag-337) is a non-classical thymidylate synthase inhibitor.
in vitro
nolatrexed was designed using x-ray crystallographic data from the ts molecular modeling and folate binding site. it is a non-classical ts inhibitor in that it lacks a terminal glutamate side chain and is uncharged at physiological ph. nolatrexed does not require a specific transport mechanism to enter into cells and, once within the cell, is not a substrate for the enzyme folyl polyglutamate synthetase [1].
in vivo
when nolatrexed was administered to nude mice bearing bu25tk- tumor xenografts, a time-dependent increase in antitumor activity was observed [1].
IC 50
1.0, 0.81 and 1.0 μm for l1210, ccrf-cem and gc3/m tk- cell lines, respectively
References
[1] hughes an, rafi i, griffin mj, calvert ah, newell dr, calvete ja, johnston a, clendeninn n, boddy av. phase i studies with the nonclassical antifolate nolatrexed dihydrochloride (ag337, thymitaq) administered orally for 5 days. clin cancer res. 1999 jan;5(1):111-8.
[2] rafi i, boddy av, calvete ja, taylor ga, newell dr, bailey np, lind mj, green m, hines j, johnstone a, clendeninn n, calvert ah. preclinical and phase i clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors. j clin oncol. 1998 mar;16(3):1131-41.
Nolatrexed dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Nolatrexed dihydrochloride Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
View Lastest Price from Nolatrexed dihydrochloride manufacturers
- Product
- Nolatrexed dihydrochloride 152946-68-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Nolatrexed dihydrochloride 152946-68-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-28